SEC FORM 3 SEC Form 3
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
 
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1. Name and Address of Reporting Person*
OrbiMed Israel GP Ltd.

(Last) (First) (Middle)
89 MEDINAT HAYEHUDIM ST
BUILDING E, 11TH FLOOR

(Street)
HERZLIYA L3 4614001

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
05/09/2017
3. Issuer Name and Ticker or Trading Symbol
Novus Therapeutics, Inc. [ NVUS ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director X 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
1. Name and Address of Reporting Person*
OrbiMed Israel GP Ltd.

(Last) (First) (Middle)
89 MEDINAT HAYEHUDIM ST
BUILDING E, 11TH FLOOR

(Street)
HERZLIYA L3 4614001

(City) (State) (Zip)
1. Name and Address of Reporting Person*
OrbiMed Israel BioFund GP Limited Partnership

(Last) (First) (Middle)
89 MEDINAT HAYEHUDIM ST
BUILDING E, 11TH FLOOR

(Street)
HERZLIYA L3 4614001

(City) (State) (Zip)
Explanation of Responses:
Remarks:
Exhibit List: Exhibit 24.1 - Power of Attorney for OrbiMed Israel GP Ltd. Exhibit 24.2 - Power of Attorney for OrbiMed BioFund Limited Partnership This report on Form 3 is jointly filed by OrbiMed Israel GP Ltd. and OrbiMed Israel BioFund GP Limited Partnership. The Reporting Persons have designated a representative, currently Erez Chimovits, to serve on the Issuer's board of directors. This report on Form 3 shall not be deemed an admission that any such entity or person, including the Reporting Persons, is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose
No securities are beneficially owned.
/s/ Ryan A. Murr, as attorney-in-fact for OrbiMed Israel GP Ltd. 05/11/2017
/s/ Ryan A. Murr, as attorney-in-fact for OrbiMed Israel BioFund Limited Partnership 05/11/2017
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
                               POWER OF ATTORNEY

         Know all by these presents, that the undersigned hereby constitutes and
appoints Gregory J. Flesher, Ryan A. Murr, and Christine Ocampo, with full power
of substitution, the undersigned's true and lawful attorney-in-fact to:

         (1)    prepare, execute in the undersigned's name and on the
                undersigned's behalf, and submit to the U.S. Securities and
                Exchange Commission (the "SEC") a Form ID, including amendments
                thereto, and any other documents necessary or appropriate to
                obtain codes and passwords enabling the undersigned to make
                electronic filings with the SEC of reports required by Section
                16(a) of the Securities Exchange Act of 1934 or any rule or
                regulation of the SEC;

         (2)    execute for and on behalf of the undersigned, in the
                undersigned's capacity as an officer and/or director of Novus
                Therapeutics, Inc. (the  "Company"), Forms 3, 4, and 5 in
                accordance with Section 16(a) of the Securities Exchange Act of
                1934 and the rules thereunder;

         (3)    do and perform any and all acts for and on behalf of the
                undersigned which may be necessary or desirable to complete and
                execute any such  Form 3,  4, or 5, complete and execute any
                amendment or amendments thereto, and timely file such form with
                the SEC and any stock exchange or similar authority; and

         (4)    take any other action of any type whatsoever in connection with
                the foregoing which, in the opinion of such attorney-in-fact,
                may be of benefit to, in the best interest of, or legally
                required by, the undersigned, it being understood that the
                documents executed by such attorney-in-fact on behalf of the
                undersigned pursuant to this Power of Attorney shall be in such
                form and shall contain such terms and conditions as such
                attorney-in-fact may approve in such attorney-in- fact's
                discretion.

         The undersigned hereby grants to such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or such
attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be
done by virtue of this power of attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorney-in-fact, in
serving in such capacity at the request of the undersigned, is not assuming, nor
is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Securities Exchange Act of 1934.

         This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorney-in-fact.

         IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 10th day of May 2017.

                                       OrbiMed Israel GP Ltd.



                                       /s/ Nissim Darvish
                                       --------------------------------
                                       Signature

                                       Nissim Darvish
                                       --------------------------------
                                       Print Name

                                       Senior Managing Director
                                       --------------------------------
                                       Print Title



                               POWER OF ATTORNEY

         Know all by these presents, that the undersigned hereby constitutes and
appoints Gregory J. Flesher, Ryan A. Murr, and Christine Ocampo, with full power
of substitution, the undersigned's true and lawful attorney-in-fact to:

         (1)    prepare, execute in the undersigned's name and on the
                undersigned's behalf, and submit to the U.S. Securities and
                Exchange Commission (the "SEC") a Form ID, including
                amendments thereto, and any other documents necessary or
                appropriate to obtain codes and passwords enabling the
                undersigned to make electronic filings with the SEC of reports
                required by Section 16(a) of the Securities Exchange Act of
                1934 or any rule or regulation of the SEC;

         (2)    execute for and on behalf of the undersigned, in the
                undersigned's capacity as an officer and/or director of Novus
                Therapeutics, Inc. (the "Company"), Forms 3, 4, and 5 in
                accordance with Section 16(a) of the Securities Exchange Act of
                1934 and the rules thereunder;

         (3)    do and perform any and all acts for and on behalf of the
                undersigned which may be necessary or desirable to complete and
                execute any such Form 3,  4, or 5, complete and execute any
                amendment or amendments thereto, and timely file such form with
                the SEC and any stock exchange or similar authority; and

         (4)    take any other action of any type whatsoever in connection with
                the foregoing which, in the opinion of such attorney-in-fact,
                may be of benefit to, in the best interest of, or legally
                required by, the undersigned, it being understood that the
                documents executed by such attorney-in-fact on behalf of the
                undersigned pursuant to this Power of Attorney shall be in such
                form and shall contain such terms and conditions as such
                attorney-in-fact may approve in such attorney-in- fact's
                discretion.

         The undersigned hereby grants to such attorney-in-fact full power and
authority to do and perform any and every act and thing whatsoever requisite,
necessary, or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or  such
attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be
done by virtue of this power of attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorney-in-fact, in
serving in such capacity at the request of the undersigned, is not assuming, nor
is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Securities Exchange Act of 1934.

         This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorney-in-fact.

         IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 10th day of May 2017.

                                  OrbiMed Israel BioFund GP Limited Partnership


                                  /s/ Nissim Darvish
                                  ----------------------------------------------
                                  Signature

                                  Nissim Darvish
                                  ----------------------------------------------
                                  Print Name

                                  Senior Managing Director
                                  ----------------------------------------------
                                  Print Title